BDBM50242737 (R,Z)-5-(2,6-dichlorobenzylsulfonyl)-3-((3,5-dimethyl-4-(2-(pyrrolidin-1-ylmethyl)pyrrolidine-1-carbonyl)-1H-pyrrol-2-yl)methylene)indolin-2-one::CHEMBL450786::PHA-665752::TCMDC-125885
SMILES Cc1[nH]c(\C=C2/C(=O)Nc3ccc(cc23)S(=O)(=O)Cc2c(Cl)cccc2Cl)c(C)c1C(=O)N1CCC[C@@H]1CN1CCCC1
InChI Key InChIKey=OYONTEXKYJZFHA-SSHUPFPWSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 11 hits for monomerid = 50242737
Affinity DataIC50: 9nMAssay Description:Inhibition of human recombinant c-MET kinase expressed in A549 cells assessed as inhibition of HGF-induced autophosphorylation by ELISA methodMore data for this Ligand-Target Pair
Affinity DataKd: 0.640nMAssay Description:Binding constant for MET(M1250T) kinase domainMore data for this Ligand-Target Pair
Affinity DataKd: 0.830nMAssay Description:Binding constant for MET(Y1235D) kinase domainMore data for this Ligand-Target Pair
Affinity DataEC50: 42nMAssay Description:Inhibition of c-Met by cellular assayMore data for this Ligand-Target Pair
Affinity DataIC50: 38nMAssay Description:Inhibition of c-Met (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 9nMAssay Description:Inhibition of c-Met (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 9nMAssay Description:Inhibition of human recombinant c-MET kinase in GTL-16 cells assessed as inhibition of HGF-induced proliferation by sandwich ELISA methodMore data for this Ligand-Target Pair
Affinity DataIC50: 9nMAssay Description:Inhibition of human c-METMore data for this Ligand-Target Pair
Affinity DataKd: 0.270nMAssay Description:Binding constant for MET kinase domainMore data for this Ligand-Target Pair
Affinity DataIC50: 38nMAssay Description:Inhibition of GST-tagged c-Met expressed in Sf9 cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 9nMAssay Description:Inhibition of c-Met by cellular assayMore data for this Ligand-Target Pair